Aim and Scope
Clinical and Translational Medicine (CTM) is an international, peer-reviewed, and open access journal with aims at promoting and accelerating the translation of preclinical research to a clinical application and the communication between basic and clinical scientists. The journal emphasizes clinical potential and application of new biotechnologies, biomaterials, bioengineering, disease-specific biomarkers, cellular and molecular medicine, omics science, bioinformatics, applied immunology, molecular imaging, drug discovery and development, and regulation and health policy. The journal is focused on the bench to bedside approach, favoring studies and clinical observations which generate hypotheses and questions relevant to the patient and disease, and guide the investigations of cellular and molecular medicine. Clinical and Translational Medicine welcomes submissions from clinicians, researchers, policy makers, and the industry.
The journal covers all areas of clinical and translational medicine (CTM) but specializes in several Themed Topics:
Education and Career Development
CTM is a major platform to exchange the knowledge and experience of clinical and translational science to increase awareness and understanding of CTM about the innovation, development, and regulation through dissemination of educational and training resources, including Graduate Communication, Educational Experience, and Talent Introduction.
Clinical Studies of Drugs and Devices
CTM offers the priority to publish results of interventional and observational studies on responses of human participants to interventions, especially evidence-based data of the improvement, efficacy, safety, toxicity, and outcomes in participants during clinical trials. CTM highly encourages clinical trials of new interventions, e.g. drugs, devices, procedures, or changes to participants' behaviors.
Target-Based Drug Discovery and Development
Target-based drug discovery and development is a major part of CTM, including target-based screening and identification, validation of target disease-specificity and drugability, computational signs and biosynthesis, drug-specific biomarkers to monitor the efficacy, drug metabolism and pharmacokinetics, target drug optimization and translation into clinical therapy. One of the focuses is protein targets, including enzyme targets, cell-signaling receptors, structural proteins and regulatory factors.
This topic devotes to articles on the application of clinical informatics, bioinformatics, medical informatics, information technology, mathematics, and omics science and clinical studies on evidence-based approaches in bioinformatics and computational medicine, including data integration and platform, methodologies, tools, big data management, and models for acquiring, storing, organizing and analyzing biomedical data to deliver diagnosis and therapy.
Clinical trans-omics is a new emerging area to integrate clinical phenomes with molecular multi-omics (e.g. genomics/proteomics/metabolomics/transcriptomics), in order to further understand molecular mechanisms of disease, patient sensitivity to therapy, and therapy design and development. This topic addresses the biomedical nature of trans-omic networks and across-points among multi-omic layers and the intrinsic connection of multi-omic profiles.
This topic is to bring single-cell transcriptomes, DNA sequencing, proteomic profiles, and images into clinical practice,
- to describe extensive heterogeneity among cells, phenotypes, spatial contexts, and cell sensitivity to therapy,
- to define new biological and functional categories of cells, and
- to provide new insights for understanding the pathogenesis and assisting precision decision for therapy.
Stem Cell Biology and Therapy
This topic highlights experimental and clinical results of stem cell isolation and expansion from adult tissues, umbilical cord blood, umbilical cord and placenta, explores their biological function and therapies. It aims to find out mechanisms that regulate stem cell pluripotency and proliferation, trafficking into peripheral blood, and homing to the damaged tissues. It deals with paracrine- and extracellular microvesicles-mediated effects of stem cell therapies, clinical ethics, regulations, trials, protocols, and practices of stem cell therapies in regenerative medicine.
This topic covers clinical and translational science of genetic and genomic research on the area of clinical potentials and applications of genomic technology, genome structure and function, genetic modification, databases, bioinformatics, clinical phenotypes and genotypes, biomarkers, precision medicine, disease genomics, pharmagenomics, comparative genomics, systems biology, and regulation policy.
Vaccines and Immunotherapy
This topic discusses identification and validation of vaccines and immunotherapy for infection and cancer, and defines influencing factors like microenvironment, neoantigens burden, immunoresistant phenotypes, and autoimmune toxicities. It addresses clinical efficacy and safety profile of vaccines and immunotherapy, effects of specific immune cell subsets, cancer neoantigens, and improvement of immune cells–driven anticancer immunity. It is focused on molecular, immunological, and clinical determinants of vaccines and combinatorial immunotherapy regimens.
Chronic Metabolic DiseasesThis topic headlines the importance of chronic metabolic disease, including obesity, diabetes, chronic cardiovascular, pulmonary, and gastroenterological diseases, liver diseases, and cancer. It investigates alterations of genomics, metabolomics, proteomics, peptidomics, glycomics, and lipidomics to explore molecular mechanisms of chronic metabolic diseases, identify disease-specific biomarkers ad therapeutic targets, and develop new therapy strategies.